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Adult patients who met the American College of Rheumatology criteria for fibromyalgia who scored >=4 on the average pain severity item of the Brief Pain Inventory (BPI) assessment were randomized in a 1:1 ratio to 12 weeks of treatment with gabapentin (n = 75) or placebo (n = 75).
The addition of an ACE inhibitor to therapy with a dihydropyridine calcium antagonist significantly reduces the incidence of peripheral edema and reflex tachycardia.
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