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Accordingly, in another embodiment, the present invention is directed toward chimeric tetracycline repressor proteins that comprise, for example, a tetracycline-binding domain derived from a revTetR protein of any of the TetR(A), TetR(B), TetR(C), TetR(D), TetR(E), TetR(G), TetR(H), TetR(J), and TetR(Z) classes of TetR binding proteins as disclosed above, that is operatively associated with a DNA-binding domain, which may be derived from another TetR repressor protein or from a non-TetR repressor, DNA-binding protein.
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